Pharmaceutical and Medical Science and Technology
Mahboobeh Naseri; Alireza Ramandi; Raheleh Rahbarian
Abstract
Diabetes is linked to heightened oxidative stress and diminished antioxidant potential, stemming from an increased generation of free radicals. The reported antioxidant attributes of saffron crocin highlight its potential in mitigating oxidative stress. The levels and functionality of BDNF (Brain-Derived ...
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Diabetes is linked to heightened oxidative stress and diminished antioxidant potential, stemming from an increased generation of free radicals. The reported antioxidant attributes of saffron crocin highlight its potential in mitigating oxidative stress. The levels and functionality of BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor) seem to undergo alterations in diabetes, primarily due to insulin resistance. These fluctuations in BDNF and NGF levels are intricately associated with the progression of type 2 diabetes.This study sought to explore the impact of crocin and safranal on the activity of antioxidant enzymes, including Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase (CAT), and neurotrophic factors derived from the brain and nerve (BDNF). Thirty-six male rats were categorized into six groups: a control group, an untreated diabetic group, and diabetic groups subjected to intraperitoneal injection of two concentrations (100 and 50 milligrams per milliliter) of crocin and safranal over a 25-day duration. At the conclusion of the treatment period, brain tissue dissection was performed to assess antioxidant enzymes BDNF and NGF.In the treatment group with a concentration of 100 milligrams per milliliter of crocin and safranal, there was a notable increase in BDNF, NGF, SOD, GPX, CAT, and MDA levels compared to the group treated with a concentration of 50 milligrams per milliliter of crocin, safranal, as well as the control group. These results suggest that crocin and safranal effectively enhance antioxidant markers and alleviate diabetes-related damages in the brain tissue of diabetic rats
Pharmaceutical and Medical Science and Technology
Mahboobeh Naseri; Alireza Ramandi; Farahnaz Mohammaditazeabadi
Abstract
The study of the pharmacological properties of saffron and its active ingredients is important considering the clinical and health applications that it can have in humans. Diabetes is a chronic disease characterized by decreased insulin secretion due to dysfunction of beta cells in the pancreas or increased ...
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The study of the pharmacological properties of saffron and its active ingredients is important considering the clinical and health applications that it can have in humans. Diabetes is a chronic disease characterized by decreased insulin secretion due to dysfunction of beta cells in the pancreas or increased insulin resistance. The tendency to treat diabetes with herbal medicines, which have fewer side effects than chemical medicines, is spreading day by day. This study was performed for the first time to investigate the effect of aqueous extract of saffron corm on blood glucose and liver enzymes in diabetic rats. Male rats were randomly divided into healthy and sick groups without treatment and treated with doses of 100, 200, and 300 mg/kg aqueous extract of saffron corm. Streptozotocin was used to induce diabetes. The mortality rate decreased significantly after the injection of saffron corm extract. Doses of 200 and 300 mg/kg of aqueous extract of saffron corm controlled weight loss in diabetic rats so that the dose of 300 mg/kg was not significant compared to control without diabetes. The results showed that injection of aqueous extract of saffron corm significantly reduced fasting blood glucose. A dose of 300 mg/kg on day 15 after induction of diabetes caused a significant decrease in blood glucose levels. It seems that one of the mechanisms of the hypoglycemic effect of saffron extract, which increases insulin secretion from pancreatic beta cells, was due to this event. A dose of 300 mg/kg decreased hepatic enzymes AST and ALT in blood serum. The results of this research showed that the aqueous extract of saffron corm, in addition to reducing blood sugar and controlling diabetes, regulated the activity of liver enzymes.
Pharmaceutical and Medical Science and Technology
ali Mohammadian; Hassan Ahmadvand; Reza Karamian; Reza Siahmansour; Ali Sepahvand; Shahram Omidvari
Abstract
Saffron is one of the most valuable food and medicine products that has a high economic importance in Iran and other countries. Harmful environmental factors prohibit the human body from collating the free radicals that are produced during breathing resulting in problems such as premature aging, atherosclerosis ...
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Saffron is one of the most valuable food and medicine products that has a high economic importance in Iran and other countries. Harmful environmental factors prohibit the human body from collating the free radicals that are produced during breathing resulting in problems such as premature aging, atherosclerosis and cancer. There has been only a few reported research studies on the antioxidant properties of Saffron petals in world. This research was carried out in order to survey the antioxidant compound that may be extracted from Saffron petals and indicate the total phenol content (TPC) and total flavonoid content (TFC) in the cultivated Saffron farms of the Lorestan province. After specifying the Saffron farms by the Random systematic method, the compound sampling was carried out (Saffron petals amount 2 kg). Then, the antioxidant activity, total amount of phenols and flavonoids in the extracts were measured by methods of DPPH, Folinciocalteau and Colorimetric assay, respectively. The results showed that the amount of IC50 was the lowest and highestin Noorabad and Vician farms with amounts of 1.66 and 156.4μg/ml, respectively by the Duncan test. The results of mean comparison showed that the total phenol content and total flavonoid content of 1098.8 mg Gallic acid/g extract and 41.39 mg cou/g extract, respectively that belonged to the Noorabad and the Chaghalvandi farms had the highest amounts among all of the saffron cultivation in the farms.
Pharmaceutical and Medical Science and Technology
Abbas Meamarbashi; Vida Hakimi
Abstract
We aimed to investigate the effect of saffron supplementation on the cardio-respiratory endurance factors in the healthy non-active girls. After filling a health and fitness questionnaire and perform 1-mile run test, 14 non-active female students were selected among the eligible students in the University ...
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We aimed to investigate the effect of saffron supplementation on the cardio-respiratory endurance factors in the healthy non-active girls. After filling a health and fitness questionnaire and perform 1-mile run test, 14 non-active female students were selected among the eligible students in the University of Mohaghegh Ardabili (Age: 20.7±1.38 years; BMI: 21.1±1.8 kg/m2) and they performed Bruce test on a computerized treadmill connected to a respiratory gas analyzer in three stages with one week interval. In this study, test has been done on subjects in stage one after placebo consumption. In the second stage, similarly test done after one week consumption of dry saffron stigma (300 mg/day) and the results were measured. Analysis of Covariance and Bonferroni pair-wise comparison were used for the data analysis. Results showed that the consumption of 300 mg saffron for one week caused a significant enhancement in VO2, VO2max, and time to exhaustion and significant reduction in the resting blood pressure and resting heart rate as well as significant increase in fat oxidation and a significant reduction in carbohydrate consumption during the Bruce test (p<0.05). It seems saffron consumption has ergogenic effect on the cardio-respiratory performance in non-active female students.
Pharmaceutical and Medical Science and Technology
B. Marjan Razavi; Mohsen Imenshahidi; Khalil Abnous; Hossein Hosseinzadeh
Abstract
(Crocus sativus L.) Commonly known as saffron, is a perennial stem less herb of the iridaceae family, widely cultivated in Iran and other countries. It is used as a flavoring and coloring agent for many thousands of years. In traditional medicine, saffron has been used for various purposes including ...
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(Crocus sativus L.) Commonly known as saffron, is a perennial stem less herb of the iridaceae family, widely cultivated in Iran and other countries. It is used as a flavoring and coloring agent for many thousands of years. In traditional medicine, saffron has been used for various purposes including abortion, as a fever reducer, an analgesic, expectorant, antispasmodic, aphrodisiac, sedative, digestive and a carminative. Various pharmacological studies have been described that saffron and its constituents exhibit different beneficial properties, including antioxidant, anticancer, anticonvulsant, antiischemic, antigenotoxic, antidote, antiapoptotic, antitussive, antidepressive, sedative and hypnotic, hypolipidemic, antinociceptive and antiinflammatory effects. Research projects have also revealed that saffron also exhibits protective effects against cardiovascular diseases including cardiac ischemia, arrhythmia, hypertension and atherosclerosis. In this review article, the effects of saffron and its active constituents on cardiovascular system were introduced.
