مروری بر اثرات قلبی عروقی زعفران و مواد مؤثره آن

نوع مقاله: مقاله علمی پژوهشی

نویسندگان

1 استادیار، مرکز تحقیقات سامانه¬های دارورسانی هدفمند، گروه فارماکودینامی و سم شناسی، دانشکده داروسازی، دانشگاه علوم پزشکی، مشهد

2 دانشیار، گروه فارماکودینامی و سم شناسی، دانشکده داروسازی، دانشگاه علوم پزشکی، مشهد

3 دانشیار، گروه شیمی دارویی، دانشکده داروسازی، دانشگاه علوم پزشکی، مشهد

4 استاد، مرکز تحقیقات علوم دارویی، گروه فارماکودینامی و سم شناسی، دانشکده داروسازی، دانشگاه علوم پزشکی، مشهد.

چکیده

گیاه زعفران با نام علمی (L. Crocus sativus) از خانواده Iridaceae، دارای کاربردهای فراوانی در دنیا و به‌ویژه ایران می‌باشد. علاوه بر کاربرد آن به‌عنوان رنگ و اسانس، زعفران دارای خواص و کاربردهای دارویی و درمانی متعددی می باشد. کلاله زعفران حاوی بیش از 150 ماده شیمیایی بوده که از میان آنها کروسین، پیکروکروسین و سافرانال در ایجاد اثرات فارماکولوژیک زعفران نقش مهمتری دارند. اثرات مفید زعفران و مواد موثره آن دربافتهای مختلف بدن چون سیستم عصبی مرکزی، دستگاه گوارش، کبد، کلیه، قلب و عروق، سیستم خون ساز ، سیستم ایمنی، چشم و سیستم اندوکرین در مطالعات درون تنی و برون تنی مشاهده شده است. خواص درمانی متعددی برای زعفران و مواد موثره آن ذکر شده است که از جمله می توان به اثرات ضد افسردگی، ضد اضطراب وخواب آوری، ضد تشنج، شل کنندگی عضلات، ضد درد و ضد التهاب، آنتی اکسیدان، آنتی آلزایمر، ضد تومور، پایین آورنده قند و چربی خون و ضد سرفه اشاره نمود. مشخص شده است که زعفران دارای اثرات حفاظت کنندگی در سیستم قلبی عروقی می باشد. مطالعات متعدد فارماکولوژیک نشان داده اند که زعفران دارای اثرات ضد آریتمی و ایسکمی قلبی، تعدیل‌کننده فشارخون، آنتی اسکلروتیک و آنتی آپوپتوتیک در بافت قلب و عروق می باشد. در این مقاله مروری به تأثیر زعفران و مواد مؤثره آن بر روی سیستم قلبی عروقی اشاره خواهد شد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Cardiovascular effects of saffron and its active constituents: A review article

نویسندگان [English]

  • B. Marjan Razavi 1
  • Mohsen Imenshahidi 2
  • Khalil Abnous 3
  • Hossein Hosseinzadeh 4
1 - Assistant Professor, Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad
2 Associate Professor, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad
3 Associate Professor, Department of Medicinal chemistry and Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad
4 Professor, Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad,
چکیده [English]

(Crocus sativus L.) Commonly known as saffron, is a perennial stem less herb of the iridaceae family, widely cultivated in Iran and other countries. It is used as a flavoring and coloring agent for many thousands of years. In traditional medicine, saffron has been used for various purposes including abortion, as a fever reducer, an analgesic, expectorant, antispasmodic, aphrodisiac, sedative, digestive and a carminative. Various pharmacological studies have been described that saffron and its constituents exhibit different beneficial properties, including antioxidant, anticancer, anticonvulsant, antiischemic, antigenotoxic, antidote, antiapoptotic, antitussive, antidepressive, sedative and hypnotic, hypolipidemic, antinociceptive and antiinflammatory effects. Research projects have also revealed that saffron also exhibits protective effects against cardiovascular diseases including cardiac ischemia, arrhythmia, hypertension and atherosclerosis. In this review article, the effects of saffron and its active constituents on cardiovascular system were introduced.

کلیدواژه‌ها [English]

  • Crocus sativus L
  • Cardiovascular
  • Crocin
  • Crocetin
  • Saffron
  • Safranal
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